Open AccessExosome-Derived miRNAs and Cellular miRNAs Activate Innate Immunity
Author(s) -
Anne Mobergslien,
Mouldy Sioud
Publication year - 2013
Publication title -
journal of innate immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.078
H-Index - 64
eISSN - 1662-8128
pISSN - 1662-811X
DOI - 10.1159/000351460
Subject(s) - innate immune system , microrna , microvesicles , exosome , biology , microbiology and biotechnology , rna interference , peripheral blood mononuclear cell , immunity , gene expression , receptor , rna , in vitro , gene , immunology , immune system , genetics
Circulating exosome-containing small RNAs have been demonstrated in vitro to be taken up by recipient cells and to alter gene expression through RNA interference. Here, we show that exosomes purified from various cancer cell lines as well as gel-purified exosomal and cellular miRNAs can induce pro-inflammatory cytokine expression in human peripheral blood mononuclear cells. Thus, circulating miRNAs may trigger innate immunity via pathogen recognition receptors, a new miRNA-activated pathway that merits some consideration.