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Clinically Relevant Effect of a New Intranasal Therapy (MP29-02) in Allergic Rhinitis Assessed by Responder Analysis
Author(s) -
Eli O. Meltzer,
Paul H. Ratner,
Claus Bachert,
Warner Carr,
William E. Berger,
Giorgio Walter Caica,
James A. Hadley,
Phil Lieberman,
Frank C. Hampel,
Joaquim Mullol,
Ullrich Munzel,
David Price,
Glenis Scadding,
J. Christian Virchow,
U. Wahn,
Ruth Murray,
Jean Bousquet
Publication year - 2013
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000351404
Subject(s) - fluticasone propionate , medicine , post hoc analysis , placebo , nasal congestion , nasal spray , nasal administration , nose , surgery , pharmacology , asthma , pathology , alternative medicine
It is unclear what constitutes a clinically meaningful response for allergic rhinitis (AR) outcomes. The objectives of these post hoc analyses were (1) to define a clinically meaningful response using novel efficacy analyses (including a responder analysis), and (2) to compare the efficacy of MP29-02 [a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP)] with commercially available FP, AZE and placebo in seasonal AR (SAR) patients, using these novel analyses.

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