The SafeBoosC Phase II Randomised Clinical Trial: A Treatment Guideline for Targeted Near-Infrared-Derived Cerebral Tissue Oxygenation versus Standard Treatment in Extremely Preterm Infants | Zendy

Adelina Pellicer | Zendy; Gorm Greisen | Zendy; Ma Benders | Zendy; Olivier Claris | Zendy; Eugene Dempsey | Zendy; Monica Fumagally | Zendy; Christian Gluud | Zendy; Cornelia Hagmann | Zendy; Lena HellströmWestas | Zendy; Simon Hyttel-Sørensen | Zendy; Petra Lemmers | Zendy; Gunnar Naulaers | Zendy; Gerhard Pichler | Zendy; Claudia Roll | Zendy; Frank van Bel | Zendy; Wim van Oeveren | Zendy; Maria Skoog | Zendy; Martin Wolf | Zendy; Topun Austin | Zendy

Open Access

The SafeBoosC Phase II Randomised Clinical Trial: A Treatment Guideline for Targeted Near-Infrared-Derived Cerebral Tissue Oxygenation versus Standard Treatment in Extremely Preterm Infants

Author(s) -

Adelina Pellicer,

Gorm Greisen,

Ma Benders,

Olivier Claris,

Eugene Dempsey,

Monica Fumagally,

Christian Gluud,

Cornelia Hagmann,

Lena HellströmWestas,

Simon Hyttel-Sørensen,

Petra Lemmers,

Gunnar Naulaers,

Gerhard Pichler,

Claudia Roll,

Frank van Bel,

Wim van Oeveren,

Maria Skoog,

Martin Wolf,

Topun Austin

Publication year - 2013

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000351346

Subject(s) - guideline , medicine , clinical trial , oxygenation , randomized controlled trial , cerebral perfusion pressure , pediatrics , anesthesia , psychological intervention , intensive care medicine , cerebral blood flow , nursing , pathology

Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo- and hyperoxia can be reduced by the combined use of close monitoring of the cerebral rStO2 and a treatment guideline to correct deviations in rStO2 outside a predefined target range.

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