Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in vitro Model of Kidney Transplant Fibrosis | Zendy

Stephanie Zell | Zendy; Roland Schmitt | Zendy; Sandra Witting | Zendy; Hans Kreipe | Zendy; Kais Hussein | Zendy; Jan U. Becker | Zendy

Open Access

Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in vitro Model of Kidney Transplant Fibrosis

Author(s) -

Stephanie Zell,

Roland Schmitt,

Sandra Witting,

Hans Kreipe,

Kais Hussein,

Jan U. Becker

Publication year - 2013

Publication title -

nephron extra

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.413

H-Index - 7

ISSN - 1664-5529

DOI - 10.1159/000351046

Subject(s) - transplantation , mesenchymal stem cell , downregulation and upregulation , biology , kidney , epithelial–mesenchymal transition , cancer research , hypoxia (environmental) , fibrosis , endocrinology , microbiology and biotechnology , medicine , chemistry , gene , biochemistry , organic chemistry , oxygen

The development of interstitial fibrosis and tubular atrophy is a common complication after kidney transplantation and is associated with reduced long-term outcome. The hallmark of tubulointerstitial fibrosis is an increase in extracellular matrix resulting from exaggerated activation of fibroblasts/myofibroblasts, and tubular atrophy is characterized by a decrease in tubular diameter and loss of function. Atrophic epithelial cells may undergo epithelial-to-mesenchymal transition (EMT) with potential differentiation into interstitial fibroblasts. One potential driver of EMT in developing interstitial fibrosis and tubular atrophy is chronic hypoxia.

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