Low Urine Vascular Endothelial Growth Factor Levels Are Associated with Mechanical Ventilation, Bronchopulmonary Dysplasia and Retinopathy of Prematurity | Zendy

Bernadette M. Levesque | Zendy; Leslie A. Kalish | Zendy; Abigail B. Winston | Zendy; Richard B. Parad | Zendy; Sonia Hernández–Dı́az | Zendy; Michele Phillips | Zendy; Amy Zolit | Zendy; JoAnn Morey | Zendy; Munish Gupta | Zendy; Akiko Mammoto | Zendy; Donald E. Ingber | Zendy; L.J. Van Marter | Zendy

Open Access

Low Urine Vascular Endothelial Growth Factor Levels Are Associated with Mechanical Ventilation, Bronchopulmonary Dysplasia and Retinopathy of Prematurity

Author(s) -

Bernadette M. Levesque,

Leslie A. Kalish,

Abigail B. Winston,

Richard B. Parad,

Sonia Hernández–Dı́az,

Michele Phillips,

Amy Zolit,

JoAnn Morey,

Munish Gupta,

Akiko Mammoto,

Donald E. Ingber,

L.J. Van Marter

Publication year - 2013

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000351040

Subject(s) - retinopathy of prematurity , bronchopulmonary dysplasia , medicine , vascular endothelial growth factor , urine , mechanical ventilation , sepsis , gastroenterology , gestation , gestational age , vegf receptors , pregnancy , biology , genetics

Organ-specific vascular endothelial growth factor (VEGF) expression is decreased during the pathogenesis of bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) several weeks before either disease can be diagnosed. Early measurement of organ-specific tissue VEGF levels might allow identification of infants at high risk for these diseases, but is not clinically feasible. Urine VEGF is easily measured and useful in early diagnosis of several diseases.

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