Frequency and Activation of CD4+CD25high FoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy | Zendy

Anna StelmaszczykEmmel | Zendy; Anna ZawadzkaKrajewska | Zendy; Agnieszka Szypowska | Zendy; Marek Kulus | Zendy; Urszula Demkow | Zendy

Open Access

Frequency and Activation of CD4+CD25high FoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy

Author(s) -

Anna StelmaszczykEmmel,

Anna ZawadzkaKrajewska,

Agnieszka Szypowska,

Marek Kulus,

Urszula Demkow

Publication year - 2013

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000350769

Subject(s) - foxp3 , immunology , medicine , il 2 receptor , allergy , pathogenesis , immune system , peripheral blood mononuclear cell , regulatory t cell , atopic dermatitis , t cell , biology , in vitro , biochemistry

Atopic allergy is among the immune tolerance-related disorders resulting from a failure of the regulatory network. Regulatory T cells (Tregs) play a leading role in the development of homeostasis in the immune system. The aim of this study was to determine the role of Tregs in the pathogenesis of atopic diseases in children by exploring the relationship between Treg frequency, activation markers and the clinical manifestations of the disease.

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