Histone Deactylase Inhibitor SAHA Induces a Synergistic HIV-1 Reactivation by 12-O-Tetradecanoylphorbol-13-Acetate in Latently Infected Cells | Zendy

Soon Young Park | Zendy; Kyung-Chang Kim | Zendy; KeeJong Hong | Zendy; Sung Soon Kim | Zendy; ByeongSun Choi | Zendy

Open Access

Histone Deactylase Inhibitor SAHA Induces a Synergistic HIV-1 Reactivation by 12-O-Tetradecanoylphorbol-13-Acetate in Latently Infected Cells

Author(s) -

Soon Young Park,

Kyung-Chang Kim,

KeeJong Hong,

Sung Soon Kim,

ByeongSun Choi

Publication year - 2013

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000350563

Subject(s) - 12 o tetradecanoylphorbol 13 acetate , methyltransferase , epigenetics , virus latency , virology , biology , virus , microbiology and biotechnology , methylation , viral replication , dna , enzyme , biochemistry , phorbol ester , protein kinase c , gene

Recent studies have reported that human immunodeficiency virus type 1 (HIV-1) proviruses are strongly suppressed in the unique epigenetic environments caused by chromatin modifications such as acetylation and methylation. Therefore, optimized therapeutic strategies directed against the virus reservoir using these epigenetic modifying agents (EMAs) should cure HIV infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research