Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol | Zendy

YuHong Jing | Zendy; KuanHsing Chen | Zendy; PeiChing Kuo | Zendy; Chia-Chi Pao | Zendy; JanKan Chen | Zendy

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Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

Author(s) -

YuHong Jing,

KuanHsing Chen,

PeiChing Kuo,

Chia-Chi Pao,

JanKan Chen

Publication year - 2013

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000350435

Subject(s) - streptozotocin , neurodegeneration , endocrinology , medicine , oxidative stress , hippocampus , diabetes mellitus , resveratrol , neuroprotection , pharmacology , disease

Diabetes mellitus-associated hyperglycemia and oxidative stress have been shown to have detrimental effects on the brain and may lead to impairment of cognitive functions. Resveratrol (Rsv), a polyphenolic antioxidant, has been shown to have moderate hypoglycemic and prominent hypolipidemic effects in diabetic rats. In the present study, we examined if Rsv improves the diabetic encephalopathy and explored its possible underlying mechanisms.

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