An Externally Accessible Linker Region in the Sodium-Coupled Phosphate Transporter PiT-1 (SLC20A1) is Important for Transport Function | Zendy

Silvia Ravera | Zendy; Heini Murer | Zendy; Ian C. Forster | Zendy

Open Access

An Externally Accessible Linker Region in the Sodium-Coupled Phosphate Transporter PiT-1 (SLC20A1) is Important for Transport Function

Author(s) -

Silvia Ravera,

Heini Murer,

Ian C. Forster

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350135

Subject(s) - xenopus , linker , cotransporter , cysteine , chemistry , cysteine metabolism , mutant , biochemistry , transmembrane domain , biophysics , thiol , microbiology and biotechnology , biology , sodium , membrane , enzyme , gene , organic chemistry , computer science , operating system

Members of the SLC20 cotransporter family (PiT-1, PiT-2) are ubiquitously expressed in mammalian tissue and are thought to perform housekeeping functions for intracellular Pi homeostasis as well as being implicated in vascular calcification and renal Pi reabsorption. The aims of this study were to investigate the topology of a linker region in PiT-1 between the predicted 2(nd) and 3(rd) transmembrane domains and to investigate the functional consequences of cysteine substitutions in this region.

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