Sgk1-Dependent Stimulation of Cardiac Na+/H+Exchanger Nhe1 by Dexamethasone | Zendy

Jakob Voelkl | Zendy; Venkanna Pasham | Zendy; Mohamed Siyabeldin E. Ahmed | Zendy; Britta Walker | Zendy; Kalina Szteyn | Zendy; Dietmar Kuhl | Zendy; Bernhard Metzler | Zendy; Ioana Alesutan | Zendy; Florian Läng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Sgk1-Dependent Stimulation of Cardiac Na⁺/H⁺Exchanger Nhe1 by Dexamethasone

Author(s) -

Jakob Voelkl,

Venkanna Pasham,

Mohamed Siyabeldin E. Ahmed,

Britta Walker,

Kalina Szteyn,

Dietmar Kuhl,

Bernhard Metzler,

Ioana Alesutan,

Florian Läng

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350120

Subject(s) - sgk1 , dexamethasone , stimulation , glucocorticoid , endocrinology , phosphorylation , medicine , messenger rna , glucocorticoid receptor , gene expression , chemistry , microbiology and biotechnology , biology , biochemistry , gene

The serum- and glucocorticoid-inducible kinase Sgk1 contributes to cardiac remodeling and development of heart failure, which is paralelled by Sgk1-dependent stimulation of the cardiac Na(+)/H(+) exchanger Nhe1. Glucocorticoids are powerful stimulators of Sgk1 expression and influence cardiac remodeling. The present study thus explored whether the glucocorticoid receptor agonist dexamethasone influenced cardiac Sgk1 expression, as well as activity, expression and phosphorylation at Ser(703) of the cardiac Na(+)/H(+) exchanger Nhe1.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research