Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4Purinergic Receptors by two Complementary Methods | Zendy

Bernadett Balázs | Zendy; Tamás Dankó | Zendy; Gergely Kovács | Zendy; László Köles | Zendy; Matthias A. Hediger | Zendy; Ákos Zsembery | Zendy

Open Access

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X₄Purinergic Receptors by two Complementary Methods

Author(s) -

Bernadett Balázs,

Tamás Dankó,

Gergely Kovács,

László Köles,

Matthias A. Hediger,

Ákos Zsembery

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350119

Subject(s) - purinergic receptor , hek 293 cells , inhibitory postsynaptic potential , receptor , intracellular , microbiology and biotechnology , transfection , recombinant dna , chemistry , p2y receptor , extracellular , ion channel , biophysics , biochemistry , biology , neuroscience , gene

ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To date, lack of specific inhibitors has hampered investigations on P2X4Rs. Recently, the benzodiazepine derivative, 5-BDBD has been proposed to selectively inhibit P2X4Rs. However, limited evidences are currently available on its inhibitory properties. Thus, we aimed to characterize the inhibitory effects of 5-BDBD on recombinant human P2X4Rs.

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