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ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To date, lack of specific inhibitors has hampered investigations on P2X4Rs. Recently, the benzodiazepine derivative, 5-BDBD has been proposed to selectively inhibit P2X4Rs. However, limited evidences are currently available on its inhibitory properties. Thus, we aimed to characterize the inhibitory effects of 5-BDBD on recombinant human P2X4Rs.

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4Purinergic Receptors by two Complementary Methods

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X₄Purinergic Receptors by two Complementary Methods