MicroRNA-22 Downregulation by Atorvastatin in a Mouse Model of Cardiac Hypertrophy: a new Mechanism for Antihypertrophic Intervention | Zendy

Yingfeng Tu | Zendy; Lin Wan | Zendy; Lihong Bu | Zendy; Dongliang Zhao | Zendy; Dandan Dong | Zendy; Tao Huang | Zendy; Zhen Cheng | Zendy; Baozhong Shen | Zendy

Open Access

MicroRNA-22 Downregulation by Atorvastatin in a Mouse Model of Cardiac Hypertrophy: a new Mechanism for Antihypertrophic Intervention

Author(s) -

Yingfeng Tu,

Lin Wan,

Lihong Bu,

Dongliang Zhao,

Dandan Dong,

Tao Huang,

Zhen Cheng,

Baozhong Shen

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350117

Subject(s) - downregulation and upregulation , pten , tensin , atorvastatin , angiotensin ii , endocrinology , microrna , medicine , muscle hypertrophy , gene knockdown , biology , stimulation , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway , cell culture , blood pressure , biochemistry , genetics , gene

Growing evidence shows that microRNAs (miRNAs) are involved in various cardiac processes including cardiac hypertrophy. However, the modulation of miRNA by pharmacological intervention in cardiomyocyte hypertrophy has not been disclosed yet. methods: We constructed neonatal rat cardiomyocyte hypertrophy induced by angiotensin II stimulation and subjected to cardiomyocyte immunochemistry, qRT-PCR and immunoblotting analysis. In addition, we constructed the mouse cardiac hypertrophy using angomir-22 stimulation and demonstrated the potential antihypertrophic mechnism of atorvastatin.

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