The Inhibition of Inwardly Rectifying K+Channels by Memantine in Macrophages and Microglial Cells | Zendy

Ke-Li Tsai | Zendy; Hsueh-Fen Chang | Zendy; ShengNan Wu | Zendy

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The Inhibition of Inwardly Rectifying K⁺Channels by Memantine in Macrophages and Microglial Cells

Author(s) -

Ke-Li Tsai,

Hsueh-Fen Chang,

ShengNan Wu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350112

Subject(s) - patch clamp , depolarization , membrane potential , biophysics , chemistry , hyperpolarization (physics) , current clamp , spermine , inhibitory postsynaptic potential , microbiology and biotechnology , neuroscience , biochemistry , receptor , biology , stereochemistry , nuclear magnetic resonance spectroscopy , enzyme

Memantine (MEM) can block N-methyl-D-aspartate receptors non-competitively and is recognized to exert anti-inflammatory action. Whether MEM and other related compounds produce any effects on K(+) currents in macrophages and in microglial cells is largely unknown. In this study, we investigated the effects of MEM and other related compounds on inwardly rectifying K(+) current (IK(IR)) in RAW 264.7 macrophages and in BV2 microglial cells.

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