Protein Kinase Ca and P-Type Ca2+Channel CaV2.1 in Red Blood Cell Calcium Signalling | Zendy

Lisa Wagner-Britz | Zendy; Jue Wang | Zendy; Lars Kaestner | Zendy; Ingolf Bernhardt | Zendy

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Protein Kinase Ca and P-Type Ca²⁺Channel Ca_V2.1 in Red Blood Cell Calcium Signalling

Author(s) -

Lisa Wagner-Britz,

Jue Wang,

Lars Kaestner,

Ingolf Bernhardt

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350106

Subject(s) - calcium , chemistry , calcium signaling , red blood cell , kinase , microbiology and biotechnology , biophysics , biochemistry , endocrinology , biology , signal transduction , organic chemistry

Protein kinase Cα (PKCα) is activated by an increase in cytosolic Ca(2+) in red blood cells (RBCs). Previous work has suggested that PKCα directly stimulates the CaV2.1 channel, whereas other studies revealed that CaV2.1 is insensitive to activation by PKC. The aim of this study was to resolve this discrepancy.

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