The Combined Effect of Retinoic Acid and LSD1 siRNA Inhibition on Cell Death in the Human Neuroblastoma Cell Line SH-SY5Y | Zendy

Guofeng Xu | Zendy; Yongtao Xiao | Zendy; Jimeng Hu | Zendy; Lili Xing | Zendy; Zhao Ou | Zendy; Yeming Wu | Zendy

Open Access

The Combined Effect of Retinoic Acid and LSD1 siRNA Inhibition on Cell Death in the Human Neuroblastoma Cell Line SH-SY5Y

Author(s) -

Guofeng Xu,

Yongtao Xiao,

Jimeng Hu,

Lili Xing,

Zhao Ou,

Yeming Wu

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350103

Subject(s) - apoptosis , sh sy5y , neuroblastoma , retinoic acid , programmed cell death , cancer research , cell culture , growth inhibition , small interfering rna , cell growth , microbiology and biotechnology , cell , chemistry , biology , transfection , biochemistry , genetics

Retinoic acid (RA) is used pharmacologically to treat neuroblastoma (NB), but its mechanism of action is unclear and it has limited use against refractory disease. This study investigated the expression of LSD1 (also known as KDM1A) in tumors, and assessed the efficacy of combining RA treatment with the inhibition of LSD1 expression.

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