1a,25-Dihydroxycholecalciferol (Vitamin D3) Induces NO-Dependent Endothelial Cell Proliferation and Migration in a Three-Dimensional Matrix | Zendy

Claudio Molinari | Zendy; Manuela Rizzi | Zendy; Diletta Francesca Squarzanti | Zendy; Pamela Pittarella | Zendy; Giovanni Vacca | Zendy; Filippo Renò | Zendy

Open Access

1a,25-Dihydroxycholecalciferol (Vitamin D3) Induces NO-Dependent Endothelial Cell Proliferation and Migration in a Three-Dimensional Matrix

Author(s) -

Claudio Molinari,

Manuela Rizzi,

Diletta Francesca Squarzanti,

Pamela Pittarella,

Giovanni Vacca,

Filippo Renò

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350099

Subject(s) - umbilical vein , enos , cell growth , microbiology and biotechnology , cell migration , wound healing , matrix (chemical analysis) , chemistry , nitric oxide , endocrinology , cell , medicine , biology , immunology , biochemistry , nitric oxide synthase , in vitro , chromatography

The 1α,25-dihydroxycholecalciferol (Vit. D) induces eNOS dependent nitric oxide (NO) production in human umbilical vein endothelial cells (HUVEC). To our knowledge, there are no reports directly relating Vit. D induced NO production to proliferation and/or migration in endothelial cells (EC). The aim of this study was to evaluate whether Vit. D addition to porcine EC could affect their proliferation and/or migration in a three-dimensional matrix via NO production.

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