Hydrogen Sulfide Inhibits Abnormal Proliferation of Lymphocytes via AKT/GSK3� Signal Pathway in Systemic Lupus Erythematosus Patients | Zendy

Yanfang Han | Zendy; Fanqin Zeng | Zendy; Guozhen Tan | Zendy; Chuntao Yang | Zendy; Hongfeng Tang | Zendy; Yijin Luo | Zendy; Jianqiang Feng | Zendy; Hui Xiong | Zendy; Qing Guo | Zendy

Open Access

Hydrogen Sulfide Inhibits Abnormal Proliferation of Lymphocytes via AKT/GSK3� Signal Pathway in Systemic Lupus Erythematosus Patients

Author(s) -

Yanfang Han,

Fanqin Zeng,

Guozhen Tan,

Chuntao Yang,

Hongfeng Tang,

Yijin Luo,

Jianqiang Feng,

Hui Xiong,

Qing Guo

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350097

Subject(s) - protein kinase b , sodium hydrosulfide , flow cytometry , systemic lupus erythematosus , viability assay , lymphocyte , cell growth , immunology , chemistry , cell cycle , signal transduction , western blot , stimulation , endocrinology , medicine , cell , hydrogen sulfide , biochemistry , disease , sulfur , organic chemistry , gene

The abnormal activation of the AKT/GSK3β signal pathway in lymphocytes from systemic lupus erythematosus (SLE) patients plays an important role in the pathogenesis of the disease. Recently Hydrogen sulfide (H2S) has been recognized as a crucial gaseous signaling molecule, involved in regulation of cell proliferation. However, the role of H2S in regulating the abnormal activation of lymphocytes from SLE patients has not been established. This study was conducted to investigate the effect of H2S on lymphocytes and to explore the mechanisms involved.

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