Activation of Cannabinoid Type 2 Receptor by JWH133 Protects Heart Against Ischemia/Reperfusion-Induced Apoptosis
Author(s) -
Qian Li,
Feng Wang,
Yanmin Zhang,
Jingjing Zhou,
Yi Zhang
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000350088
Subject(s) - cannabinoid receptor type 2 , ischemia , reperfusion injury , cannabinoid receptor , apoptosis , protein kinase b , pharmacology , pi3k/akt/mtor pathway , agonist , cytochrome c , ischemic preconditioning , cannabinoid , chemistry , medicine , endocrinology , receptor , biology , biochemistry
Cannabinoid type 2 (CB2) receptor agonists can protect myocardium against ischemia/reperfusion (I/R) injury although the underlying mechanism remains unclear. Here we report the antiapoptotic effect of CB2 receptor agonist, JWH133, during myocardial ischemia/reperfusion injury and potential underlying mechanisms.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom