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Activation of Cannabinoid Type 2 Receptor by JWH133 Protects Heart Against Ischemia/Reperfusion-Induced Apoptosis
Author(s) -
Qian Li,
Feng Wang,
Yanmin Zhang,
Jingjing Zhou,
Yi Zhang
Publication year - 2013
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000350088
Subject(s) - cannabinoid receptor type 2 , ischemia , reperfusion injury , cannabinoid receptor , apoptosis , protein kinase b , pharmacology , pi3k/akt/mtor pathway , agonist , cytochrome c , ischemic preconditioning , cannabinoid , chemistry , medicine , endocrinology , receptor , biology , biochemistry
Cannabinoid type 2 (CB2) receptor agonists can protect myocardium against ischemia/reperfusion (I/R) injury although the underlying mechanism remains unclear. Here we report the antiapoptotic effect of CB2 receptor agonist, JWH133, during myocardial ischemia/reperfusion injury and potential underlying mechanisms.

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