Human Bone Marrow Stromal Cells can Differentiate to a Retinal Pigment Epithelial Phenotype when Co-Cultured with Pig Retinal Pigment Epithelium using a Transwell System | Zendy

Ping Duan | Zendy; Haiwei Xu | Zendy; Yuxiao Zeng | Zendy; Yi Wang | Zendy; Zheng Qin Yin | Zendy

Open Access

Human Bone Marrow Stromal Cells can Differentiate to a Retinal Pigment Epithelial Phenotype when Co-Cultured with Pig Retinal Pigment Epithelium using a Transwell System

Author(s) -

Ping Duan,

Haiwei Xu,

Yuxiao Zeng,

Yi Wang,

Zheng Qin Yin

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000350080

Subject(s) - stromal cell , retinal pigment epithelium , microbiology and biotechnology , neurotrophic factors , retina , retinal , biology , bone marrow , cell culture , secretion , chemistry , pathology , immunology , cancer research , medicine , endocrinology , neuroscience , receptor , biochemistry , genetics

There is an increasing interest in generating retinal pigment epithelial (RPE) cells from stem cells for therapy against degenerative eye diseases. Human bone marrow stromal cells (hBMSCs) can be induced to express retinal neuron-specific markers when co-cultured with retinal neurons, however, whether hBMSCs can differentiate into RPE-like cells in a co-culture system has not been clarified.

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