A Qualitative Seminested PCR Assay as an Alternative to Urine Cytology for BK Polyomavirus Screening after Renal Transplantation | Zendy

Ana Carolina Jonard Zalona | Zendy; Rafael Brandão Varella | Zendy; Christina Maeda Takiya | Zendy; Renato Torres Gonçalves | Zendy; Mariano Zalis | Zendy; Guilherme SantoroLopes | Zendy

Open Access

A Qualitative Seminested PCR Assay as an Alternative to Urine Cytology for BK Polyomavirus Screening after Renal Transplantation

Author(s) -

Ana Carolina Jonard Zalona,

Rafael Brandão Varella,

Christina Maeda Takiya,

Renato Torres Gonçalves,

Mariano Zalis,

Guilherme SantoroLopes

Publication year - 2013

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000349896

Subject(s) - urine cytology , cytology , urine , transplantation , kidney transplantation , kidney , urology , bk virus , medicine , biology , pathology , cancer , bladder cancer

Polyomavirus-associated nephropathy (PVAN) is a major cause of graft dysfunction after kidney transplantation. Therefore, routine screening for BK polyomavirus (BKV) infection with urine cytology or quantitative PCR-based assays has been recommended. Although less expensive than quantitative tests, qualitative PCR assays are not recommended for screening based on the assumption that their diagnostic accuracy is inferior to urine cytology. However, studies comparing the performance of both methods are scarce.

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