Discrepancies of HIV-1 Reverse Transcriptase Resistance Interpretation of Insertions and Deletions between Two Genotypic Algorithms | Zendy

Giselle Ibete Silva LópezLopes | Zendy; André Minhoto Lança | Zendy; João Leandro de Paula Ferreira | Zendy; Luciana Oliveira Souza | Zendy; Luís Fernando de Macedo Brígido | Zendy

Open Access

Discrepancies of HIV-1 Reverse Transcriptase Resistance Interpretation of Insertions and Deletions between Two Genotypic Algorithms

Author(s) -

Giselle Ibete Silva LópezLopes,

André Minhoto Lança,

João Leandro de Paula Ferreira,

Luciana Oliveira Souza,

Luís Fernando de Macedo Brígido

Publication year - 2013

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000348511

Subject(s) - indel , reverse transcriptase , genetics , biology , genotyping , indel mutation , genotype , algorithm , sequence (biology) , gene , rna , mathematics , single nucleotide polymorphism

Bioinformatics algorithms have been developed for the interpretation of resistance from sequence submission, which supports clinical decision making. This study evaluated divergences of the interpretation of the genotyping in two commonly used algorithms, using sequences with indels of reverse transcriptase genes.

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