Transglutaminase 2 Accelerates Vascular Calcification in Chronic Kidney Disease | Zendy

Neal X. Chen | Zendy; Kalisha O’Neill | Zendy; Xianming Chen | Zendy; Kraiwiporn Kiattisunthorn | Zendy; Vincent H. Gattone | Zendy; Sharon M. Moe | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Transglutaminase 2 Accelerates Vascular Calcification in Chronic Kidney Disease

Author(s) -

Neal X. Chen,

Kalisha O’Neill,

Xianming Chen,

Kraiwiporn Kiattisunthorn,

Vincent H. Gattone,

Sharon M. Moe

Publication year - 2013

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000347031

Subject(s) - calcification , vascular smooth muscle , endocrinology , medicine , fibronectin , extracellular matrix , kidney , kidney disease , chemistry , biochemistry , smooth muscle

Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that can cross-link nearly all extracellular matrix (ECM) proteins and can facilitate cell-ECM interaction through integrins. Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate vascular calcification in chronic kidney disease (CKD).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research