Urine Catalytic Iron and Neutrophil Gelatinase-Associated Lipocalin as Companion Early Markers of Acute Kidney Injury after Cardiac Surgery: A Prospective Pilot Study | Zendy

Krittapoom Akrawinthawong | Zendy; Michael K. Shaw | Zendy; Joshua Kachner | Zendy; Eugene O. Apostolov | Zendy; Alexie G. Basnakian | Zendy; Sudhir V. Shah | Zendy; Jacqueline Tilak | Zendy; Peter A. McCullough | Zendy

Open Access

Urine Catalytic Iron and Neutrophil Gelatinase-Associated Lipocalin as Companion Early Markers of Acute Kidney Injury after Cardiac Surgery: A Prospective Pilot Study

Author(s) -

Krittapoom Akrawinthawong,

Michael K. Shaw,

Joshua Kachner,

Eugene O. Apostolov,

Alexie G. Basnakian,

Sudhir V. Shah,

Jacqueline Tilak,

Peter A. McCullough

Publication year - 2013

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000346815

Subject(s) - medicine , acute kidney injury , urine , lipocalin , biomarker , creatinine , cardiopulmonary bypass , urinary system , cardiac surgery , gastroenterology , urology , surgery , biochemistry , chemistry

Open heart surgery with cardiopulmonary bypass is recognized as a common cause of acute kidney injury (AKI). The conventional biomarker creatinine is not sensitive enough to detect AKI until a significant decline in renal filtration has occurred. Urine neutrophil gelatinase-associated lipocalin (NGAL), part of an acute response to the release of tissue iron from cells, is an early biomarker and a predictor of AKI in a variety of clinical settings. We sought to evaluate the relationship between urine catalytic iron (unbound iron) and NGAL over the course of AKI due to cardiac surgery.

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