Inhibitory Effect of Mitomycin C on Proliferation of Primary Cultured Fibroblasts from Human Airway Granulation Tissues | Zendy

Nan Chen | Zendy; Jie Zhang | Zendy; Min Xu | Zendy; Yu Ling Wang | Zendy; Ying Hua Pei | Zendy

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Inhibitory Effect of Mitomycin C on Proliferation of Primary Cultured Fibroblasts from Human Airway Granulation Tissues

Author(s) -

Nan Chen,

Jie Zhang,

Min Xu,

Yu Ling Wang,

Ying Hua Pei

Publication year - 2013

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000346648

Subject(s) - granulation tissue , mitomycin c , medicine , fibroblast , mtt assay , in vitro , andrology , viability assay , pharmacology , microbiology and biotechnology , wound healing , immunology , surgery , biology , biochemistry

Airway granulation tissue and scar formation pose a challenge because of the high incidence of recurrence after treatment. As an emerging treatment modality, topical application of mitomycin C has potential value in delaying the recurrence of airway obstruction. Several animal and clinical studies have already proven its feasibility and efficacy. However, the ideal dosage has still not been determined.

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