Soluble CD23 Levels are Inversely Associated with Atopy and Parasite-Specific IgE Levels but Not with Polyclonal IgE Levels in People Exposed to Helminth Infection | Zendy

Nadine Rujeni | Zendy; Norman Nausch | Zendy; Nicholas Midzi | Zendy; Reginald Gwisai | Zendy; Takafira Mduluza | Zendy; David W. Taylor | Zendy; Francisca Mutapi | Zendy

Open Access

Soluble CD23 Levels are Inversely Associated with Atopy and Parasite-Specific IgE Levels but Not with Polyclonal IgE Levels in People Exposed to Helminth Infection

Author(s) -

Nadine Rujeni,

Norman Nausch,

Nicholas Midzi,

Reginald Gwisai,

Takafira Mduluza,

David W. Taylor,

Francisca Mutapi

Publication year - 2013

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000346545

Subject(s) - immunoglobulin e , atopy , cd23 , immunology , polyclonal antibodies , biology , medicine , allergy , antibody

Protective acquired immunity against helminths and allergic sensitisation are both characterised by high IgE antibody levels. Levels of IgE antibodies are naturally tightly regulated by several mechanisms including binding of the CD23 receptor. Following observations that helminth infections and allergic sensitisation may co-present, the current study aims to investigate the relationship between the soluble CD23 (sCD23) receptor, parasite-specific IgE responses and allergic sensitisation in people exposed to the helminth parasite Schistosoma haematobium.

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