Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma | Zendy

Yohei Mano | Zendy; Shinichi Aishima | Zendy; Nobuhiro Fujita | Zendy; Yuki Tanaka | Zendy; Yuichiro Kubo | Zendy; Takashi Motomura | Zendy; Akinobu Taketomi | Zendy; Ken Shirabe | Zendy; Yoshihiko Maehara | Zendy; Yoshinao Oda | Zendy

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Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma

Author(s) -

Yohei Mano,

Shinichi Aishima,

Nobuhiro Fujita,

Yuki Tanaka,

Yuichiro Kubo,

Takashi Motomura,

Akinobu Taketomi,

Ken Shirabe,

Yoshihiko Maehara,

Yoshinao Oda

Publication year - 2013

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000346196

Subject(s) - stat3 , cancer research , stat protein , hepatocellular carcinoma , tumor progression , cell growth , tumor associated macrophage , cytokine , metastasis , immunohistochemistry , biology , medicine , pathology , signal transduction , tumor microenvironment , cancer , tumor cells , microbiology and biotechnology , genetics

Signal transducer and activator of transcription 3 (STAT3) is activated in hepatocellular carcinoma (HCC), and tumor-associated macrophage plays an important role in tumor progression. Therefore, we examined STAT3 activation, cytokine expression and infiltration of tumor-associated macrophages in resected HCCs as well as the alteration of cell growth and migration by cytokine stimulation in HCC cell lines.

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