Genetic Variation at NCAN Locus Is Associated with Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity | Zendy

Alexis Gorden | Zendy; Rongze Yang | Zendy; Laura M. YergesArmstrong | Zendy; Kathleen A. Ryan | Zendy; Elizabeth K. Speliotes | Zendy; Ingrid B. Borecki | Zendy; Tamara B. Harris | Zendy; Xin Chu | Zendy; G. Craig Wood | Zendy; Christopher D. Still | Zendy; Alan R. Shuldiner | Zendy; Glenn S. Gerhard | Zendy

Open Access

Genetic Variation at NCAN Locus Is Associated with Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity

Author(s) -

Alexis Gorden,

Rongze Yang,

Laura M. YergesArmstrong,

Kathleen A. Ryan,

Elizabeth K. Speliotes,

Ingrid B. Borecki,

Tamara B. Harris,

Xin Chu,

G. Craig Wood,

Christopher D. Still,

Alan R. Shuldiner,

Glenn S. Gerhard

Publication year - 2013

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000346195

Subject(s) - steatohepatitis , fatty liver , medicine , steatosis , single nucleotide polymorphism , genome wide association study , fibrosis , biology , metabolic syndrome , obesity , endocrinology , gastroenterology , disease , genotype , genetics , gene

Obesity-associated non-alcoholic fatty liver disease (NAFLD) may cause liver dysfunction and failure. In a previously reported genome-wide association meta-analysis, single nucleotide polymorphisms (SNPs) near PNPLA3, NCAN, GCKR, LYPLAL1 and PPP1R3B were associated with NAFLD and with distinctive serum lipid profiles. The present study examined the relevance of these variants to NAFLD in extreme obesity.

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