Short-Term Folate Supplementation in Physiological Doses Has No Effect on ESR1 and MLH1 Methylation in Colonic Mucosa of Individuals with Adenoma | Zendy

Reyad Abbadi | Zendy; Peter W. Emery | Zendy; Maria Pufulete | Zendy

Open Access

Short-Term Folate Supplementation in Physiological Doses Has No Effect on ESR1 and MLH1 Methylation in Colonic Mucosa of Individuals with Adenoma

Author(s) -

Reyad Abbadi,

Peter W. Emery,

Maria Pufulete

Publication year - 2012

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000345819

Subject(s) - methylenetetrahydrofolate reductase , medicine , methylation , placebo , mlh1 , endocrinology , dna methylation , homocysteine , colorectal cancer , colorectal adenoma , chemistry , cancer , genotype , pathology , biochemistry , gene expression , alternative medicine , dna mismatch repair , gene

Low folate intake may increase risk of colorectal cancer by altering gene-specific methylation in the colon. We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen receptor 1 (ESR1) and mutL homolog 1 (MLH1) genes in colonic mucosa of subjects with colorectal adenoma.

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