Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations | Zendy

Laura Gabriela SánchezLozada | Zendy; Miguel A. Lanaspa | Zendy; Magdalena Cristóbal-García | Zendy; Fernando E. GarcíaArroyo | Zendy; Virgilia Soto | Zendy; David CruzRobles | Zendy; Takahiko Nakagawa | Zendy; Min Yu | Zendy; DukHee Kang | Zendy; Richard J. Johnson | Zendy

Open Access

Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations

Author(s) -

Laura Gabriela SánchezLozada,

Miguel A. Lanaspa,

Magdalena Cristóbal-García,

Fernando E. GarcíaArroyo,

Virgilia Soto,

David CruzRobles,

Takahiko Nakagawa,

Min Yu,

DukHee Kang,

Richard J. Johnson

Publication year - 2012

Publication title -

nephron experimental nephrology

Language(s) - English

Resource type - Journals

ISSN - 1660-2129

DOI - 10.1159/000345509

Subject(s) - endothelial dysfunction , endocrinology , oxidative stress , medicine , uric acid , hyperuricemia , mitochondrion , mitochondrial ros , aconitase , nitric oxide , xanthine oxidase , chemistry , endothelium , intracellular , biology , biochemistry , enzyme

Endothelial dysfunction is associated with mitochondrial alterations. We hypothesized that uric acid (UA), which can induce endothelial dysfunction in vitro and in vivo, might also alter mitochondrial function.

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