Increased Expression Levels of Integrin α9β1 and CD11b on Circulating Neutrophils and Elevated Serum IL-17A in Elderly Aspiration Pneumonia | Zendy

Yasuyuki Taooka | Zendy; Miki Ohe | Zendy; Lijun Chen | Zendy; Akihisa Sutani | Zendy; Yusuke Higashi | Zendy; Takeshi Isobe | Zendy

Open Access

Increased Expression Levels of Integrin α9β1 and CD11b on Circulating Neutrophils and Elevated Serum IL-17A in Elderly Aspiration Pneumonia

Author(s) -

Yasuyuki Taooka,

Miki Ohe,

Lijun Chen,

Akihisa Sutani,

Yusuke Higashi,

Takeshi Isobe

Publication year - 2012

Publication title -

respiration

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.264

H-Index - 81

eISSN - 1423-0356

pISSN - 0025-7931

DOI - 10.1159/000345390

Subject(s) - cd18 , medicine , integrin alpha m , integrin , pneumonia , aspiration pneumonia , immunology , receptor , flow cytometry

Repeated aspiration pneumonia is a serious problem in the elderly. In aspiration pneumonia, neutrophils play an important role in acute lung injury, while CD18-independent neutrophil transmigration pathways have also been reported in acid-aspiration pneumonia animal models. However, the involvement of IL-17A and β1 integrin still remains unclear. The β1 integrin subfamily integrin α9β1 has been shown to be expressed on human neutrophils and to mediate adhesion to extracellular matrix proteins including the vascular cell adhesion molecule-1.

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