Ghrelin and Obestatin in Human Neuroendocrine Tumors: Expression and Effect on Obestatin Levels after Food Intake | Zendy

Malin Grönberg | Zendy; Apostolos V. Tsolakis | Zendy; Ulf Holmbäck | Zendy; Mats Stridsberg | Zendy; Lars Grimelius | Zendy; Eva Tiensuu Janson | Zendy

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Ghrelin and Obestatin in Human Neuroendocrine Tumors: Expression and Effect on Obestatin Levels after Food Intake

Author(s) -

Malin Grönberg,

Apostolos V. Tsolakis,

Ulf Holmbäck,

Mats Stridsberg,

Lars Grimelius,

Eva Tiensuu Janson

Publication year - 2012

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000345366

Subject(s) - obestatin , ghrelin , medicine , endocrinology , peptide yy , pancreatic polypeptide , hormone , neuropeptide , glucagon , neuropeptide y receptor , receptor

Ghrelin and obestatin are derived from the same peptide hormone precursor and are mainly produced by the gastric mucosa. Ghrelin is involved in many biological processes, whereas the physiological function of obestatin needs further investigation. The aims of the present study were to establish the incidence of ghrelin- and obestatin-immunoreactive cells in a comprehensive panel of human neuroendocrine tumors (NETs) and to investigate if blood obestatin concentrations are influenced during a standardized meal stimulation test in healthy individuals and patients with NETs.

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