Donepezil Abolishes Anticholinergic Activity in a Patient with Amnesia | Zendy

Kimiko Konishi | Zendy; Koji Hori | Zendy; Hiroi Tomioka | Zendy; Genshin Minegishi | Zendy; Masayuki Tani | Zendy; Hiroaki Tanaka | Zendy; Ryo Akita | Zendy; Sachiko Yokoyama | Zendy; Tomonori Oshio | Zendy; Mitsugu Hachisu | Zendy

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Donepezil Abolishes Anticholinergic Activity in a Patient with Amnesia

Author(s) -

Kimiko Konishi,

Koji Hori,

Hiroi Tomioka,

Genshin Minegishi,

Masayuki Tani,

Hiroaki Tanaka,

Ryo Akita,

Sachiko Yokoyama,

Tomonori Oshio,

Mitsugu Hachisu

Publication year - 2012

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000345344

Subject(s) - donepezil , anticholinergic , amnesia , cholinesterase , medicine , dementia , alzheimer's disease , cognitive decline , psychology , anesthesia , disease , psychiatry

We report the case of a 74-year-old woman who presented with amnesia and positive serum anticholinergic activity (SAA), which disappeared after treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer's disease pathology combined to generate SAA in this patient. We also consider that SAA may have subsequently become negative because of upregulation of acetylcholine production by donepezil, and because the patient's other medications and physical condition (including glaucoma) remained unchanged during the 1-year period.

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