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Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples
Author(s) -
Knut Gubbe,
Yvonne Scharnagl,
Steffi Grosch,
Torsten Tonn,
Michael Schmidt,
Kai Hourfar,
Andreas Karl,
Erhard Seifried,
Ina Wilkemeyer,
Ulrich Kalus
Publication year - 2012
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000345319
Subject(s) - nat , coefficient of variation , virology , human immunodeficiency virus (hiv) , blood donor , blood donations , medicine , chromatography , immunology , chemistry , computer network , computer science
Commercial available NAT systems are usually not validated for screening of post-mortem blood samples. NAT testing might be challenging due to inhibitory substances in the cadaveric blood sample that cause false-negative test results. Validation studies have to be performed to show the performance characteristics of the NAT assays for testing cadaveric blood.

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