Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review | Zendy

Daniel Bergman | Zendy; Matilda Halje | Zendy; Matilda Nordin | Zendy; Wilhelm Engström | Zendy

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Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review

Author(s) -

Daniel Bergman,

Matilda Halje,

Matilda Nordin,

Wilhelm Engström

Publication year - 2012

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000343995

Subject(s) - growth factor , biology , disease , genomic imprinting , cancer , insulin like growth factor 2 , allele , imprinting (psychology) , insulin like growth factor , insulin like growth factor 2 receptor , gene , cancer research , receptor , bioinformatics , genetics , immunology , insulin like growth factor 1 receptor , gene expression , medicine , dna methylation

Insulin-like growth factor 2 (IGF2) is a protein hormone known to regulate cell proliferation, growth, migration, differentiation and survival. The gene is parentally imprinted in the sense that transcripts are almost exclusively derived from the paternal allele. Loss of imprinting of the IGF2 gene is a recurrent observation in growth disorders that combine overgrowth with a variety of malignant tumours. Moreover, IGF2 has been proposed to play a role in the development of a variety of seemingly unrelated cancers that play an important role in geriatric medicine, e.g., breast cancer, colon cancer and lung cancer. Finally, IGF2 has been implicated in cardiovascular disease, since, for example, IGF2 has been shown to influence the size of atherosclerotic lesions.

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