Open AccessAmino Acid Substitutions in the Core Region Associate with Insulin Resistance in Chronic Hepatitis C
Author(s) -
ChaoHung Hung,
TsungHui Hu,
Chuan–Mo Lee,
Chao-Min Huang,
ChienHung Chen,
JingHoung Wang,
ShengNan Lu
Publication year - 2013
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000343913
Subject(s) - steatosis , insulin resistance , medicine , odds ratio , body mass index , endocrinology , hepatitis c virus , genotype , gastroenterology , biology , insulin , virology , virus , genetics , gene
Hepatitis C virus (HCV) core protein can induce liver steatosis and glucose intolerance in transgenic mice. We aimed to clarify the association of HCV core region heterogeneity with the development of insulin resistance (IR) among patients with chronic hepatitis C (CHC).
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