Challenging False Discovery Rate: A Partition Test Based on p Values in Human Case-Control Association Studies | Zendy

Jürg Ott | Zendy; Zhe Liu | Zendy; Yuanyuan Shen | Zendy

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Challenging False Discovery Rate: A Partition Test Based on p Values in Human Case-Control Association Studies

Author(s) -

Jürg Ott,

Zhe Liu,

Yuanyuan Shen

Publication year - 2012

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000343752

Subject(s) - false discovery rate , single nucleotide polymorphism , snp , trait , multiple comparisons problem , partition (number theory) , genetic association , genetics , statistics , quantitative trait locus , mathematics , locus (genetics) , biology , combinatorics , gene , genotype , computer science , programming language

We consider the situation that multiple genetic variants are underlying a heritable trait and assume that each contributes to the trait only to a small degree. The aim is to develop a statistical test for disease association of these multiple variants.

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