Alteration of Histone H3 Lysine 4 Trimethylation on Putative Lytic Gene Promoters by Human Set1 Complex during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus | Zendy

Jae Eun Jong | Zendy; Seho Cha | Zendy; Jun Hyeong Jang | Zendy; Taegun Seo | Zendy

Open Access

Alteration of Histone H3 Lysine 4 Trimethylation on Putative Lytic Gene Promoters by Human Set1 Complex during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus

Author(s) -

Jae Eun Jong,

Seho Cha,

Jun Hyeong Jang,

Taegun Seo

Publication year - 2013

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000343749

Subject(s) - lytic cycle , h3k4me3 , histone h3 , biology , chromatin immunoprecipitation , histone , prc2 , kaposi's sarcoma associated herpesvirus , promoter , microbiology and biotechnology , epigenetics , histone methylation , gene , cancer research , dna methylation , gene expression , virology , genetics , herpesviridae , virus , viral disease

Histone H3 lysine 4 is trimethylated by the human Set1 complex, which regulates the activation of gene expression. The aim of this study was to identify whether the levels of histone H3 lysine 4 trimethylation (H3K4me3) and the recruitment of human Set1 complex at the promoter regions of lytic genes quantitatively change during reactivation from latent to lytic infection of Kaposi's sarcoma-association herpesvirus (KSHV).

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