Comparison of the Diagnostic Performance of Three Natriuretic Peptides in Hemodialysis Patients: Which is the Appropriate Biomarker? | Zendy

Ferruh Artunç | Zendy; Christian Mueller | Zendy; Tobias Breidthardt | Zendy; Raphael Twerenbold | Zendy; I. Rettig | Zendy; Engin Usta | Zendy; HansUlrich Häring | Zendy; Björn Friedrich | Zendy

Open Access

Comparison of the Diagnostic Performance of Three Natriuretic Peptides in Hemodialysis Patients: Which is the Appropriate Biomarker?

Author(s) -

Ferruh Artunç,

Christian Mueller,

Tobias Breidthardt,

Raphael Twerenbold,

I. Rettig,

Engin Usta,

HansUlrich Häring,

Björn Friedrich

Publication year - 2012

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000343406

Subject(s) - interquartile range , medicine , hemodialysis , natriuretic peptide , brain natriuretic peptide , cardiology , diuresis , heart failure , natriuresis , biomarker , atrial natriuretic peptide , endocrinology , ambulatory , incidence (geometry) , renal function , chemistry , physics , optics , biochemistry

Plasma concentrations of natriuretic peptides are often elevated in chronic hemodialysis patients and difficult to interpret due to accumulation, high incidence of cardiac disease and changes in volume status. Mid-regional pro-ANP is a newly developed assay whereas BNP and its fragment NT-pro-BNP are available for a longer time. In this cross-sectional study, we compared the plasma concentration of MR-pro-ANP, BNP and NT-pro-BNP in stable ambulatory hemodialysis patients (n = 239) and investigated their associations with clinical factors such as residual diuresis, cardiac status and interdialytic weight gain and with mortality.

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