Chloride Channel Blockers Suppress Formation of Engulfment Pseudopodia in Microglial Cells | Zendy

Barbara Harl | Zendy; Judith Schmölzer | Zendy; Martin Jakab | Zendy; Markus Ritter | Zendy; Hubert Kerschbaum | Zendy

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Chloride Channel Blockers Suppress Formation of Engulfment Pseudopodia in Microglial Cells

Author(s) -

Barbara Harl,

Judith Schmölzer,

Martin Jakab,

Markus Ritter,

Hubert Kerschbaum

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343370

Subject(s) - pseudopodia , microglia , phagocytosis , microbiology and biotechnology , biophysics , tonicity , flow cytometry , chemistry , pinocytosis , extracellular , biology , cell , endocytosis , biochemistry , inflammation , immunology

Phagocytosis depends on the formation of engulfment pseudopodia surrounding the target. We tested in microglia, monocyte-derived cells in the brain, whether a swelling-activated Cl(-)-current (I(Cl,swell)), required for global cell volume (CV) regulation, also contributes to local expansion and retraction of engulfment pseudopodia.

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