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Smooth muscle tone is controlled by Ca(2+) signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40) and Cx37, which allow the exchange of signaling molecules to coordinate their activity. Here, we investigated the role of Cx40 in the endothelial Ca(2+) signaling of the mouse aorta.

Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca2+Signaling in Mouse Aortic Endothelium

Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca²⁺Signaling in Mouse Aortic Endothelium