Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca2+Signaling in Mouse Aortic Endothelium | Zendy

François-Xavier Boittin | Zendy; Florian Alonso | Zendy; Loïc Le Gal | Zendy; Florent Allagnat | Zendy; JeanLouis Bény | Zendy; JacquesAntoine Haefliger | Zendy

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Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca²⁺Signaling in Mouse Aortic Endothelium

Author(s) -

François-Xavier Boittin,

Florian Alonso,

Loïc Le Gal,

Florent Allagnat,

JeanLouis Bény,

JacquesAntoine Haefliger

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343358

Subject(s) - carbenoxolone , muscarinic acetylcholine receptor , gap junction , microbiology and biotechnology , purinergic receptor , endothelium , receptor , acetylcholine , medicine , endocrinology , paracrine signalling , chemistry , biology , intracellular , extracellular

Smooth muscle tone is controlled by Ca(2+) signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40) and Cx37, which allow the exchange of signaling molecules to coordinate their activity. Here, we investigated the role of Cx40 in the endothelial Ca(2+) signaling of the mouse aorta.

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