The GAP Portion ofPseudomonas AeruginosaType III Secreted Toxin ExoS Upregulates Total and Surface Levels of Wild Type CFTR | Zendy

Deepali N. Tukaye | Zendy; SangHo Kwon | Zendy; Wiliam B. Guggino | Zendy

Open Access

The GAP Portion ofPseudomonas AeruginosaType III Secreted Toxin ExoS Upregulates Total and Surface Levels of Wild Type CFTR

Author(s) -

Deepali N. Tukaye,

SangHo Kwon,

Wiliam B. Guggino

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343357

Subject(s) - wild type , gtpase activating protein , transfection , cell culture , chemistry , microbiology and biotechnology , biology , g protein , mutant , biochemistry , signal transduction , gene , genetics

Pseudomonas aeruginosa (PA) infections account for a large percentage of fatal hospital acquired pneumonias. One of the PA Type III secreted toxin (TTST) ExoS, a bifunctional protein with N-terminal GTPase activating protein (GAP) and C-terminal ADP rybosyl transferase (ADPRT) activities, significantly contributes to PA virulence by targeting small molecular weight G-proteins (SMWGP). In this study, we have looked at one of the mechanisms by which the GAP portion of ExoS (ExoS-GAP) mediates cellular toxicity.

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