Ras Activated ERK and PI3K Pathways Differentially Affect Directional Movement of Cultured Fibroblasts | Zendy

Leandra Sepe | Zendy; Maria Carla Ferrari | Zendy; Concita Cantarella | Zendy; Francesca Fioretti | Zendy; Giovanni Paolella | Zendy

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Ras Activated ERK and PI3K Pathways Differentially Affect Directional Movement of Cultured Fibroblasts

Author(s) -

Leandra Sepe,

Maria Carla Ferrari,

Concita Cantarella,

Francesca Fioretti,

Giovanni Paolella

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343355

Subject(s) - mapk/erk pathway , pi3k/akt/mtor pathway , wound healing , cell migration , microbiology and biotechnology , cell , effector , biology , chemistry , signal transduction , immunology , biochemistry

Cell migration is essential in physiological and pathological processes, such as wound healing and metastasis formation. Ras involvement in these processes has been extensively demonstrated. This work attempts to characterize Ras regulation of the phenomena determining directional cell migration by separately analyzing the role of its principal effector pathways, MAPK and PI3K.

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