SIRT1 Regulates the Human Alveolar Epithelial A549 Cell Apoptosis Induced byPseudomonas AeruginosaLipopolysaccharide | Zendy

Xiaoli Liu | Zendy; Kuiqing Shao | Zendy; Tieying Sun | Zendy

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SIRT1 Regulates the Human Alveolar Epithelial A549 Cell Apoptosis Induced byPseudomonas AeruginosaLipopolysaccharide

Author(s) -

Xiaoli Liu,

Kuiqing Shao,

Tieying Sun

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343352

Subject(s) - a549 cell , apoptosis , viability assay , microbiology and biotechnology , lipopolysaccharide , chemistry , programmed cell death , biology , biochemistry , immunology

Sirtuin1 (SIRT1) is an NAD(+)-dependent deacetylase that plays an inhibitory role in cell apoptosis, which is associated with p53 deacetylation. Lipopolysaccharide (LPS) is a key virulence factor produced by Pseudomonas aeruginosa and plays an important role in mediating the interactions between the bacterium and its host. However, the effect of SIRT1 in the regulation of LPS-induced human alveolar epithelial A549 cells apoptosis is unknown.

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