Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis | Zendy

Yuhua Fan | Zendy; Congrong Wang | Zendy; Yong Zhang | Zendy; Pengzhou Hang | Zendy; Yan Liu | Zendy; Zhenwei Pan | Zendy; Ning Wang | Zendy; Zhimin Du | Zendy

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Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Author(s) -

Yuhua Fan,

Congrong Wang,

Yong Zhang,

Pengzhou Hang,

Yan Liu,

Zhenwei Pan,

Ning Wang,

Zhimin Du

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343351

Subject(s) - arsenic trioxide , apoptosis , calcium in biology , pharmacology , cardiac function curve , tunel assay , p38 mitogen activated protein kinases , medicine , herg , mapk/erk pathway , chemistry , endocrinology , calcium , kinase , potassium channel , heart failure , biochemistry

Arsenic trioxide (As2O3) is a highly effective agent for treatment of acute promyelocytic leukemia (APL). However, consecutively administered As2O3 induces serious adverse cardiac effects, including long QT syndrome (LQTs) and even sudden cardiac death. Previous studies have shown that genistein (Gen) exerts anti-oxidant, anti-inflammatory, and anti-apoptotic effects. The present study aimed to explore the potential protective effects of Gen on As2O3-induced adverse cardiac effects, and to elucidate the underlying molecular mechanisms.

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