Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt | Zendy

Petra Waskova-Arnostova | Zendy; Barbara Elsnicová | Zendy; Dita Kašparová | Zendy; Ondřej Šebesta | Zendy; Jiřı́ Novotný | Zendy; Ján Neckář | Zendy; František Kolář | Zendy; Jitka Žurmanová | Zendy

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Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt

Author(s) -

Petra Waskova-Arnostova,

Barbara Elsnicová,

Dita Kašparová,

Ondřej Šebesta,

Jiřı́ Novotný,

Ján Neckář,

František Kolář,

Jitka Žurmanová

Publication year - 2013

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343350

Subject(s) - phosphorylation , protein kinase b , hexokinase , microbiology and biotechnology , medicine , mitochondrion , biology , endocrinology , chemistry , glycolysis , metabolism

Hexokinase (HK) is a key glycolytic enzyme which promotes the maintenance of glucose homeostasis in cardiomyocytes. HK1 isoform is predominantly bound to the outer mitochondrial membrane and highly supports oxidative phosphorylation by increasing the availability of ADP for complex V of the respiratory chain. HK2 isoform is under physiological conditions predominantly localized in the cytosol and upon stimulation of PI3K/ Akt pathway associates with mitochondria and thus can prevent apoptosis. The purpose of this study was to investigate expression and subcellular localization of both HK isoforms in left (LV) and right (RV) heart ventricles of adult male Wistar rats.

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