Up-Regulation of Amino Acid Transporter SLC6A19 Activity and Surface Protein Abundance by PKB/Akt and PIKfyve | Zendy

Evgenii Bogatikov | Zendy; Carlos Muñoz | Zendy; Tatsiana Pakladok | Zendy; Ioana Alesutan | Zendy; Manzar Shojaiefard | Zendy; Guiscard Seebohm | Zendy; Michael Föller | Zendy; Mònica Palmada | Zendy; Christoph Böhmer | Zendy; Stefan Bröer | Zendy; Florian Läng | Zendy

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Up-Regulation of Amino Acid Transporter SLC6A19 Activity and Surface Protein Abundance by PKB/Akt and PIKfyve

Author(s) -

Evgenii Bogatikov,

Carlos Muñoz,

Tatsiana Pakladok,

Ioana Alesutan,

Manzar Shojaiefard,

Guiscard Seebohm,

Michael Föller,

Mònica Palmada,

Christoph Böhmer,

Stefan Bröer,

Florian Läng

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343341

Subject(s) - protein kinase b , phosphorylation , microbiology and biotechnology , biochemistry , akt1 , pi3k/akt/mtor pathway , biology , amino acid , chemistry , signal transduction

The amino acid transporter B0AT1 (SLC6A19) accomplishes concentrative cellular uptake of neutral amino acids. SLC6A19 is stimulated by serum- & glucocorticoid-inducible kinase (SGK) isoforms. SGKs are related to PKB/Akt isoforms, which also stimulate several amino acid transporters. PKB/Akt modulates glucose transport in part by phosphorylating and thus activating phosphatidylinositol-3-phosphate-5-kinase (PIKfyve), which fosters carrier protein insertion into the cell membrane. The present study explored whether PKB/Akt and/or PIKfyve stimulate SLC6A19.

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