Mesenchymal Stem Cells Support Proliferation and Terminal Differentiation of B Cells | Zendy

Yue Ji | Zendy; Yang Zhou | Zendy; Zhibo Han | Zendy; Lei Meng | Zendy; Liang Lu | Zendy; Xiao Feng | Zendy; Shao Guang Yang | Zendy; Ying Chi | Zendy; Dan Dan Chen | Zendy; You Wei Wang | Zendy; Zhongchao Han | Zendy

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Mesenchymal Stem Cells Support Proliferation and Terminal Differentiation of B Cells

Author(s) -

Yue Ji,

Yang Zhou,

Zhibo Han,

Lei Meng,

Liang Lu,

Xiao Feng,

Shao Guang Yang,

Ying Chi,

Dan Dan Chen,

You Wei Wang,

Zhongchao Han

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343340

Subject(s) - mesenchymal stem cell , microbiology and biotechnology , in vivo , in vitro , stem cell , biology , cellular differentiation , immunology , bone marrow , chemistry , biochemistry , gene

Mesenchymal stem cells (MSC) play important roles in modulating the activities of T lymphocytes, dendritic cells and natural killer cells. These immunoregulatory properties of MSC suggest their therapeutic potential in autoimmune diseases. However, the effects of MSC on B cells are still poorly understood. The present study was designed to investigate the interaction between MSC and B cells both in vitro and in vivo, and to determine the possible mechanism of action.

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