Antagonistic Effects of a 50 Hz Magnetic Field and Melatonin in the Proliferation and Differentiation of Hepatocarcinoma Cells | Zendy

María Antonia Cid | Zendy; Alejandro Úbeda | Zendy; María Luisa HernándezBule | Zendy; María Antonia Martínez | Zendy; María Ángeles Trillo | Zendy

Open Access

Antagonistic Effects of a 50 Hz Magnetic Field and Melatonin in the Proliferation and Differentiation of Hepatocarcinoma Cells

Author(s) -

María Antonia Cid,

Alejandro Úbeda,

María Luisa HernándezBule,

María Antonia Martínez,

María Ángeles Trillo

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343338

Subject(s) - melatonin , microbiology and biotechnology , cell growth , cellular differentiation , endocrinology , biology , medicine , chemistry , cancer research , physics , biochemistry , gene

Epidemiological and experimental evidence exists indicating that exposure to weak, extremely low frequency magnetic fields (ELF - MF) could affect cancer progression. It has been proposed that such hypothetical action could be mediated by MF-induced effects on the cellular response to melatonin (MEL), a potentially oncostatic neurohormone. The present study investigates the response of HepG2 cells to intermittent exposure to a 50 Hz, 10 µT MF, in the presence or absence of MEL at physiological (10 nM) or pharmacological doses (1 µM).

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