Down-Regulation of the Myoinositol Transporter SMIT by JAK2 | Zendy

Zohreh Hosseinzadeh | Zendy; Shefalee K. Bhavsar | Zendy; Florian Läng | Zendy

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Down-Regulation of the Myoinositol Transporter SMIT by JAK2

Author(s) -

Zohreh Hosseinzadeh,

Shefalee K. Bhavsar,

Florian Läng

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343335

Subject(s) - inositol , osmotic concentration , transporter , xenopus , biology , microbiology and biotechnology , chemistry , medicine , endocrinology , biochemistry , receptor , gene

Janus-activated kinase-2 JAK2 is activated by energy depletion and hyperosmotic shock and modifies the activity of several Na(+) coupled transporters. The Na(+) coupled osmolyte transporter SMIT (myoinositol transporter) is upregulated by osmotic shock and downregulated by energy depletion. The present study thus explored whether JAK2 contributes to the regulation of SMIT activity.

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