Low Molecular Weight Heparin Inhibits Circulating Fibrocytes Differentiation by Modulating Neuronal Nitric Oxide Synthase and TGF-�1/Smad Pathway | Zendy

Xudong Xie | Zendy; Liangfeng Zhu | Zendy; Zhongying Fu | Zendy; Xiaogang Guo | Zendy; Kan Wang | Zendy; Xiaosheng Hu | Zendy; Jun-zhu Chen | Zendy

Open Access

Low Molecular Weight Heparin Inhibits Circulating Fibrocytes Differentiation by Modulating Neuronal Nitric Oxide Synthase and TGF-�1/Smad Pathway

Author(s) -

Xudong Xie,

Liangfeng Zhu,

Zhongying Fu,

Xiaogang Guo,

Kan Wang,

Xiaosheng Hu,

Jun-zhu Chen

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000343334

Subject(s) - smad , transdifferentiation , western blot , flow cytometry , nitric oxide synthase , chemistry , nitric oxide , endocrinology , blot , gene isoform , medicine , transforming growth factor , microbiology and biotechnology , biology , biochemistry , stem cell , gene

Circulating fibrocytes (CFs) have been placed at the center of a number of fibrosing conditions. Recently, attention has been drawn to the non-anticoagulant activities of low molecular weight heparin (LH), especially its anti-fibrotic effects. The purpose of this study was to investigate the effects of LH on CFs differentiation and possible underlying mechanisms.

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